Abstract
The polyphenolic-rich extract of Tunisian Origanum glandulosum Desf. was investigated for its phenolic composition, antioxidant activity and potential to contribute to the dietary management of type II diabetes. By mean of an ultra-performance liquid chromatography-electrospray ionization- mass spectrometry (UPLC-PDA-ESI-MS) 16 phenolics were characterized. The major detected compounds are caffeic acid, luteloin glucoside, xanthomicrol and carvacrol. The polyphenolic-rich extract presented a notable antioxidant activity similar to that of the synthetic antioxidant Trolox. It was found to inhibit, in a concentration dependent manner, the α-amylase activity with an IC50 value (8.22 mg/mL) comparable to that of Acarbose (6.12 mg/mL). Overall, our findings suggest that O. glandulosum could be considered as a valuable source of high-value phytochemicals with pharmaceutical and functional food additive applications. Practical Applications Origanum glandulosum Desf., a North African endemic species, is one of the most used plants in folk medicine against whooping cough, fever, bronchitis and diabetes. In the present work, the ability of O. glandulosum to inhibit pancreatic α-amylase in vitro as well as to act as antioxidant food was investigated. The results suggest that O. glandulosum could be considered as a valuable source of phytochemicals with a potent α-amylase inhibition property and antioxidant capacity. Further animal and clinical studies were needed to confirm the potential use of O. glandulosum for the management of type II diabetes.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.