Abstract
Article history: Marine algae are known to produce an extensive variety of bioactive metabolites and several novel drugs have been derived for the pharmaceutical industries. However glycoproteins from the algae have not been adequately explored for their potential as a source of bioactive substances. The objectives of this study were to investigate the antioxidant activity effect of glycoprotein (GLP). In the experiment of the radical elimination ability by means of 1,1-diphenyl-2-picryhydrazyl (DPPH) expressed anti-oxidative effect depending on the concentration considering GLP. Hydroxyl (OH) radical, superoxide radical (O2) and nitric oxide radial (NO) scavenging also showed that antioxidant abilities in the dose depended concentration. These results express that GLP eliminates reactive oxygen species (ROS), protect cell membrane, and can act as antioxidants. Therefore, it is thought that GLP can be used to new material of food supplements related to antioxidants.
Highlights
Seaweed contains diverse biological activity in potential medicinal value, such as anticoagulant, antiangiogenic, anti-inflammatory, antitumor, antiviral, and antioxidant (Athukorala et al, 2007; Dias et al, 2005; Chang et al, 2008; Zhu et al, 2006; Zhou et al, 2008)
Our group reported that the extraction and purification of glycoprotein (GLP) with a molecular mass of ∼48 kDa from C. decorticatum
The purified fraction was confirmed in the SDS-PAGE of Periodic acid–Schiff (PAS) staining that the detected protein is a glycoprotein
Summary
Seaweed contains diverse biological activity in potential medicinal value, such as anticoagulant, antiangiogenic, anti-inflammatory, antitumor, antiviral, and antioxidant (Athukorala et al, 2007; Dias et al, 2005; Chang et al, 2008; Zhu et al, 2006; Zhou et al, 2008). Antioxidants can prevent or delay the oxidizable substrates in the cell. This mechanism in two ways: ROS scavenging and inhibiting the generation of ROS. The alternative natural antioxidant from available biological sources and interest of extensive finding has arisen. Nowadays there is an interest to recognize and exploit anti-oxidative compounds in many natural sources, seaweeds and their different extracts have confirmed strong antioxidant activity (Yuan and Walsh, 2006)
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