Abstract
A new diarylbutane lignan, 2′-hydroxy dihydroguaiaretic acid ( 4), and a known 8- O-4′-type neolignan, machilin D ( 5), were isolated from the ethyl acetate extracts of the underground parts of Saururus chinensis. Compounds 4 and 5 exhibited low-density lipoprotein (LDL)-antioxidant activity in the thiobarbituric acid-reactive substances (TBARS) assay ( 4: IC 50 = 3.3 μM and 5: IC 50 = 3.8 μM), the lag time of conjugated diene production, the relative electrophoretic mobility (REM) of ox-LDL, the apoB-100 fragmentation on copper-mediated LDL oxidation and the macrophage-mediated LDL oxidation, and radical DPPH scavenging activity.
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