Abstract
The ethyl acetate and chloroform extracts of stems, leaves and fruits of Phaleria macrocarpa were screened for their antioxidant capacity and tyrosinase inhibition properties. The total phenolic content (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging and ferric-ion reducing power (FRAP) were used to evaluate their antioxidant capacity. Tyrosinase inhibition effect was measured using mushroom tyrosinase inhibition assay. Ethyl acetate extract of P. macrocarpa's stem exhibited highest total phenolic content, DPPH free radical scavenging and ferric reducing power. Meanwhile, chloroform extracts of leaves and fruits demonstrated potent anti-tyrosinase activities as compared to a well-known tyrosinase inhibitor, kojic acid. Since chloroform extracts of leaves and fruits have low antioxidant capacities, the tyrosinase inhibition effect observed are antioxidant independent. This study suggests direct tyrosinase inhibition by chloroform extracts of Phaleria macrocarpa.
Highlights
Cellular metabolisms generate reactive oxygen species (ROS)
The skin as an organ is quite vulnerable to oxidative stress given its continuous exposure to direct ultraviolet (UV), radiation from sunlight that can cause hyperpigmentation and pre-matured aging (Kim et al, 2008; Heo et al, 2009)
The present study investigated the total phenolic content, free radical scavenging activities, ferric reducing antioxidant power and tyrosinase inhibition of P. macrocarpa extracts from different parts
Summary
Cellular metabolisms generate reactive oxygen species (ROS). excessive production of ROS contributes significantly to oxidative stress. ROS causes oxidation of proteins, lipids, DNA and may leads to cell death (Ragu et al, 2007). The skin as an organ is quite vulnerable to oxidative stress given its continuous exposure to direct ultraviolet (UV), radiation from sunlight that can cause hyperpigmentation and pre-matured aging (Kim et al, 2008; Heo et al, 2009). Melanin is a protective barrier against UV radiation from the sunlight, accumulation of an abnormal amount of melanin in different specific parts of the skin results in the development of freckles or melasma which may affect the patient’s quality of life (Chang, 2009). The present study investigated the total phenolic content, free radical scavenging activities, ferric reducing antioxidant power and tyrosinase inhibition of P. macrocarpa extracts from different parts
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: African Journal of Traditional, Complementary and Alternative Medicines
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
