Abstract
Aims: Aim was to evaluate the anti-osteoporotic and anti-osteoarthritic activity of fresh water snail (Viviparous bengalensis) (VB) flesh extract (VBE) in experimental model. Settings and Design: Experimental osteoporosis (OSP) was developed in female Wistar rats by bilateral overectomy and Osteoarthritis (OA) was developed in male Wistar rats by bacterial collagenase injection. Methods and Material: VB was collected locally and authenticated, then homogenized in 3500 rpm × 15 mins and supernatant was collected. Rats were divided into-Group-1: Sham control, Group-2: OSP/OA control, Group-3: Standard (vitD3 200 mg·kg -1; p.o., calcium i.p. 1500 mg·kg -1 × 15 days in OSP and indomethacin 0.25 mg·kg-1, p.o. × 5 alternative days in OA), Group-4: VBE treated (1 gm·kg-1; p.o. × 15 days), Group-5: VBE treated (2 mg·kg-1; p.o. × 15 days). Anti-osteoporotic and anti-osteoarthritic activity of VBE was examined through physical, urinary and serum parameters. Statistical use: Data were expressed in terms of mean ± SEM (n = 6). ANOVA was performed, p Key findings: It was observed that the body weight, ankle/ knee diameters, urinary markers hydroxyproline/glucosamine/calcium/phosphate/creatinine, serum ACP/ALP/TRAP, calcium/creatinine, cytokines (TNF-α/IL-1β/CINC-1) levels were changed significantly and restored after VBE treatment. Significance: Fresh water snail flesh extract possess anti-osteoporosis and anti-osteoarthritic activity in experimental animal models.
Highlights
Osteoporosis and Osteoarthritis are the two common bone-joint related diseases occur throughout the world especially among the elders population [1,2]
Key Findings: It was observed that the body weight, ankle/ knee diameters, urinary markers hydroxyproline/glucosamine/calcium/phosphate/creatinine, serum ACP/ALP/TRAP, calcium/creatinine, cytokines (TNF-α/IL-1β/CINC-1) levels were changed significantly and restored after Viviparous bengalensis extract (VBE) treatment
Urinary hydroxyproline [16] and glucosamine [17,18] showed that the increased hydroxyproline level in albino rats of osteoporosis and osteoarthritic group significantly lower in treated group
Summary
Osteoporosis and Osteoarthritis are the two common bone-joint related diseases occur throughout the world especially among the elders population [1,2]. Osteoporosis affects both sexes and all races, albeit to different degrees [3]. Osteoporosis is one of the (“porous bones”, in Greek: ortho means “bone” and poros meaning “pore”) common disease of bones that leads to an increased risk of fracture. It is seen after menopause, as the hormonal levels are altered at that time. As a result bone mineral density (BMD) is reduced, bone microarchitecture deteriorates, and the
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