Anti-obesity effects of resveratrol, black tea extract and caffeine in mice

Abstract

OF THE THESIS Anti-Obesity Effects of Resveratrol, Black Tea Extract, and Caffeine in Mice by Tzu-Ying Chen Thesis Advisor: Dr. Qingrong Huang Obesity continues to be a major public health issue in the United States. The aims of this study were to investigate whether the dietary resveratrol, black tea extract, caffeine and their combination could show anti-obesity effects in CD-1 mice fed with a high-fat diet. Five groups of CD-1 mice, with 10 mice in each group, were fed with 0.06 % resveratrol (RTL), 0.2 % black tea extract (BTE) and 0.05 % caffeine (CF), as well as their combination containing 0.03 % RTL, 0.1 % BTE and 0.025 % CF for 16 weeks. Mice on the CF diet significantly (p<0.01) reduced body weight gain by 46 %, while those on the RTL, BTE, CF and the combination diets showed reductions by 12 %, 14 % and 28 %, respectively. There were significant inhibitions in parametrial (77 %), retroperitoneal (77 %) fat pads and brown adipose tissue (57 %) for mice on CF group.