Abstract
BackgroundObesity is a major health concern both in developed and developing countries. The use of herbal medicines became the subject of interest for the management of obesity due to its natural origin, cost effectiveness and minimal side effects. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL).MethodsIn this study, the rats were randomly divided into six groups i.e., (1) Normal Diet (ND); (2) Normal Diet and 175 mg/kgBW of EECCL (ND + 175 mg/kgBW); (3) Normal Diet and 350 mg/kgBW of EECCL (ND + 350 mg/kgBW); (4) High Fat Diet (HFD); (5) High Fat Diet and 175 mg/kgBW of EECCL (HFD + 175 mg/kgBW); (6) High Fat Diet and 350 mg/kgBW of EECCL (HFD + 350 mg/kgBW). The anti-obesity potential was evaluated through analyses of changes in body weight, visceral fat weight, and blood biochemicals including total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), leptin, insulin, adiponectin, ghrelin and fecal fat content. In addition, metabolite profiling of EECCL was carried out using NMR spectroscopy.ResultsRats receiving EECCL together with HFD showed significant (p < 0.05) reduction in body weight gain compared to rats receiving HFD only. At the end of study, the body weight gain of EECCL treated rats was not significantly (p > 0.05) different with those of ND rats. Other related obesity biomarkers including plasma lipid profiles, insulin, leptin, ghrelin and adiponectin levels also showed significant improvement (p < 0.05). Administration of EECCL caused significant (p < 0.05) increase in fecal fat excretion, which validates the hypothesis of lipase inhibition, an anti-obesity mechanism similar to standard drug of Orlistat. The 1H-NMR spectra of EECCL ascertained the presence of catechin, quercetin, rutin, kaempherol and chlorogenic acid in the extract.ConclusionConclusively, EECCL showed anti-obesity properties by inhibition of intestinal lipid absorption and modulation of adipocytes markers.
Highlights
Obesity is a major health concern both in developed and developing countries
Results from preliminary study on Cosmos caudatus Kunth extracted with different concentration of ethanol and water (100:0, 80:20, 60:40, 50:50 and 40:60) showed that Cosmos caudatus Kunth extracted with 100% ethanol (EECCL) exhibited best pancreatic lipase, antioxidant activity and highest phenolic and flavonoid content [34]
The different extracting solvent used in preparation of Cosmos caudatus Kunth extracts were important for the recovery of phenolic and flavonoid compounds and it was found that 100% ethanol (EECCL) was the most efficient solvent for extracting those compounds
Summary
Obesity is a major health concern both in developed and developing countries. The present study aimed at investigating anti-obesity potential of ethanolic extract from Cosmos caudatus Kunth leaf (EECCL). It is estimated that over 205 million men and 297 million women were obese, which account for a total of more than 600 million adults worldwide [2]. Obesity has been considered as a major health concern both in developed and developing countries. It is associated with various comorbidities including hyperlipidemia, diabetes, fatty liver, cancer and atherosclerosis [3,4,5,6]. Prevention of obesity is very crucial, in adults and in children
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
