Abstract
BackgroundLotus (Nelumbo nucifera) leaf has been used to treat obesity. The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in high fat diet-induced obese rats.MethodsFour week-old male Sprague-Dawley rats were randomly divided into four groups with 8 rats in each group for a period of 6 weeks (normal diet, N group; high fat diet, HF group; high fat diet + lotus leaf hot water extract, HFL group; high fat diet + lotus leaf hot water extract + taurine, HFLT group). Lotus leaf hot water extract was orally administrated to HFL and HFLT groups and the same amount of distilled water was orally administered (400 mg/kg/day) to N and HF groups. Taurine was supplemented by dissolving in feed water (3% w/v).ResultsThe body weight gain and relative weights of epididymal and retroperitoneal adipose tissues were significantly lower in N, HFL and HFLT groups compared to HF group. HFL and HFLT groups showed lower concentrations of total cholesterol, triglyceride and low density lipoprotein cholesterol in serum. HFLT group showed higher the ratio of high density lipoprotein cholesterol/total cholesterol compared to HFL group. HFLT group showed better blood lipid profiles compared to HFL group.ConclusionsLotus leaf hot water extract with taurine supplementation showed antiobesity and hypolipidemic effects in high fat diet-induced obese rats, which was more effective than lotus leaf hot water extract alone.
Highlights
Lotus (Nelumbo nucifera) leaf has been used to treat obesity
These results suggest that lotus leaf hot water extract and taurine may prevent an increase of body weight induced by a high fat diet; it seemed that low body weight in HFL and HFLT groups
The adipose tissue weights (E-fat and retroperitoneal fat (R-fat)) of HF group were significantly higher compared to other groups
Summary
The purpose of this study was to investigate the antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in high fat diet-induced obese rats. Taurine supplementation can improve serum lipid profiles in rats [15] and mice[16], and decrease serum TG concentration in overweight or obese humans[17]. Both lotus leaf and taurine have highly safe properties, and can be served as raw materials for functional foods with antiobesity. This research was conducted to evaluate antiobesity and hypolipidemic effects of lotus leaf hot water extract with taurine supplementation in rats fed a high fat diet
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