Abstract
We evaluated the antioxidant and porcine pancreatic lipase inhibition (PPLI) activities of 90 plants extracts. The antioxidant activity was measured using the free-radical scavenging capacity (DPPH) and reducing power (RP) assays. The pancreatic lipase inhibition assay was used to determine the PPLI activity of plant extracts. Among the 90 plant extracts examined, 41.0 % crude extracts showed antilipase activity of more than 50%. The most active plants by means of IC50 value were Camellia sinensis (0.5 mg/ml), Ceratonia siliqua (leaves) (0.8 mg/mL), Curcuma longa (0.8 mg/mL), Sarcopoterium spinosum (1.2 mg/mL), and Mentha spicata (1.2 mg/mL). The antioxidant activity of plant extracts using the DPPH and RP assays reveals comparable results. The most active antioxidant extracts using both assays were the leaves and fruit epicarp of Rhus coriaria, areal parts of Sarcopoterium spinosum, and leaves of Ceratonia siliqua. Our results suggest natural resources that possess strong antioxidant and pancreatic lipase inhibitory activities with potential applications in the treatment and prevention of obesity and overweight. The extracts of Camellia sinensis, Ceratonia siliqua, Curcuma longa, Sarcopoterium spinosum, and Mentha spicata were proved to have a great potential as antioxidants and antiobesity agents.
Highlights
Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health
Using the pancreatic lipase inhibition assay, the pancreatic lipase inhibition activity was determined by measuring the hydrolysis of p-nitrophenol butyrate (pNPB) to p-nitrophenol at 410 nm [42]
The scavenging effects on DPPH radicals were determined by measuring the decay in absorbance at 517 nm due to the DPPH radical reduction, indicating the antioxidant activity of the compounds in a short time [49, 50]
Summary
Overweight and obesity are defined as abnormal or excessive fat accumulation that may impair health. Body mass index (BMI) is a crude population measure of obesity that is commonly used to classify overweight and obesity in adults; it is defined as a person’s weight in kilograms divided by the square of their height in meters (kg/m2). According to the recent WHO report, more than 1.9 billion adults, 18 years and older, were overweight in 2016, of these over 650 million were obese. Most of the world's population lives in countries where overweight and obesity kill more people than underweight; obesity has reached epidemic proportions globally, with about 2.8 million people dying each year as a result of being overweight or obese [1]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Evidence-Based Complementary and Alternative Medicine
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
