Abstract
Obesity is caused by imbalanced food intake and physical activity. Obesity is associated with severe metabolic diseases such as type 2 diabetes. Silk peptide, derived from Bombyx mori cocoons, is a natural biomaterial that has various applications in biotechnology and bio‐pharmacology in Asian countries. However molecular mechanism of the anti‐obesity and anti‐diabetic effect has not been elucidated. In this study, we investigated the molecular mechanism of adipogenesis inhibition induced by silk peptide on 3T3‐L1 adipocytes. Our data show that silk peptide decreased lipid accumulation and early adipogenic factors in a dose‐dependent manner. Silk peptide inhibited the protein expression of early adipogenic transcription factors, such as CCAAT/enhancer‐binding protein beta(C/EBP α) and peroxisome proliferator‐activated receptor gamma (PPARγ) compared with control. In addition, the anti‐diabetes effect of silk peptide was evidenced by the up‐regulation of GLUT4 expression. Our findings suggest that silk peptide suppresses adipocyte differentiation and promotes glucose uptake ability. Silk peptide may be a safe, effective and economical food grade ingredient for obese patients.
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