Abstract
The current study was designed to assess the preliminary antinociceptive, sedative and muscle relaxants activates of crude extract and various solvent fractions of Caralluma tuberculata using established in-vivo protocols. The results illustrated significant (P<0.05) antinociceptive activity of extract/fractions of the plant in a dose dependent manner (50 and 100 mg/kg i.p.). When studied in open field test, the extracts and fractions of the plant demonstrated significant (P<0.05) sedative effect. Similarly, the extracts and fractions had (P<0.05) muscle relaxant effect on traction test. However, hexane was the only fraction which did not exhibit significant activity in either of the tests. The current investigation, suggest that Caralluma tuberculata contain potential molecules with antinociceptive, seadtive and muscle relaxant activities.
Highlights
C. tuberculata is herb growing in dry hilly area of K.P.K Dir, Pakistan
The literature revealed that C. tuberculata contains luteolin-4ʹ-O-neohesperidoside with a significant anti-inflammatory and antinociceptive activity [2,3]
Plant Material: C. tuberculata was collected from the mountain area of Mago, Razagram, Toormang, Dir, Khyber Pakhtunkhwa Pakistan in the month of November 2011
Summary
It has an endangered plant used to cure diabetes and to control fat accumulation. C. tuberculata is herb growing in dry hilly area of K.P.K Dir, Pakistan. It is known as Pamanky in Pashto and cooked and eaten as a vegetable [1]. C. attenuata is used as a folk medicine for the treatment of diabetes and rheumatism. The literature revealed that C. tuberculata contains luteolin-4ʹ-O-neohesperidoside with a significant anti-inflammatory and antinociceptive activity [2,3]. Some of biological activity of the plant such as phytochemical composition, phytotoxic potential, and antioxidant capacity has already been reported [4,5]
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