Abstract
Chronic experiments on rats have shown that serotonin in a dose of 50-160 micrograms injected into the lateral ventricle of the brain raised the threshold of the vocalisating response of the animals to the stimulation of tail tissues by single electric impulses. Methisergide (0.5 mg/kg, i.p.), a blocker of serotonin receptors, prevented the development of the antinociceptive effect of serotonin. Naloxon (2 mg/kg, s. c.), a morphine antagonist, did not affect the antinociceptive effect of serotonin.
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