Abstract
Background: Reactive oxygen species (ROS) is known to be involved in chronic and persistent pain. By using the ROS scavenger 5,5-dimethyl-1-pyrroline N-oxide (DMPO), we studied the effects of ROS on formalin-induced nociception in rats. Methods: 5% formalin was injected in the left hind paw after intraperitoneal injection of saline or various doses of DMPO (10 mg/kg, 30 mg/kg, 100 mg/kg). Number of flinches was measured in a 5 minute interval for 1 hour. Results: Formalin injected into the left hind paw induced a biphasic nociceptive behaviour. Intraperitoneal injection of DMPO diminished nociceptive behaviors dose-dependently during phase 2 but not phase 1. Conclusions: ROS might be involved in central sensitization and DMPO, a ROS scavenger, posses antinociceptive property in rats subjected to formalin induced hyperalgesia. (Korean J Anesthesiol 2008; 54: S 35～9)
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