Abstract
A chemical investigation on the roots of Aconitum episcopale afforded three undescribed aconitine–type C19–diterpenoid alkaloids, episcopalines A–C (1–3). The structures of the new compounds were elucidated by spectroscopic analysis (NMR, IR, UV, and MS). The isolated alkaloids were tested in vivo for their antinociceptive properties. As a result, episcopaline B (2) showed potent antinociceptive effect and its ID50 value (55.0 μmol/kg) was 2-fold less than those of the positive control drugs aspirin and acetaminophen.
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