Abstract
To investigate the ethanolic root bark extract of Icacina senegalensis for antinociceptive, anti-inflammatory and antipyretic activities in rats and mice. Acetic acid-induced abdominal constriction and tail immersion tests were used to evaluate the antinociceptive activity of the extract. Egg albumin and carrageenan-induced paw oedema were used to study the anti-inflammatory activity, whereas the anti-pyretic studies were evaluated on yeast and amphetamine-induced pyrexia. The root bark extract (50, 100 and 200 mg/kg) significantly (P
Highlights
IntroductionJuss (Family: Icacinaceae) is a savannah suffurex with glabrous or pubescent leafy shoots of about 2-3 feet high and a large fleshy tuber with creeping roots
Result shows that ethanolic root bark extract of Icacina senegalensis possesses phytochemicals with therapeutic potential against painful, inflammatory and feverish conditions, and explain the use of Icacina senegalensis for similar ailments in traditional medicine
Collection of the root bark The roots of Icacinia senegalensis were collected from a farm land in Orlu, Imo state, Nigeria .The plant material was identified and authenticated by a taxonomist in the department of Botany, University of Calabar, Nigeria
Summary
Juss (Family: Icacinaceae) is a savannah suffurex with glabrous or pubescent leafy shoots of about 2-3 feet high and a large fleshy tuber with creeping roots. The plant is indigenous to west and central Africa (Sarr et al, 2011; Mbatchou and Dawada, 2012). It grows wild on light sandy soils in the savannah areas of Senegal, Gambia, Ghana, Nigeria, Guinea, Central African Republic, Congo and parts of Sudan. The plant was reported to exhibit antimalarial activity (David-Oku et al, 2014), antimicrobial (Obiajunwa-Otteh et al, 2014), and antihyperglycemic actions ( N’diaye et al, 2008; Akuodor et al, 2014). Despite its popular traditional application for the treatment of pains and feverish conditions, no scientific report of this plant on pains and feverish conditions has been verified.
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