Abstract
Synadenium umbellatum Pax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail flick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test. EES and MF reduced the number of acetic acid-induced abdominal writhes, while CF and HF did not. EES effect on acetic acid-induced abdominal writhing was reversed with a pretreatment with naloxone. EES reduced licking time in both phases of the formalin-induced paw licking test, but did not prolong the latency in the tail flick test. These results show that EES presented antinociceptive activity, probably involving the opioid system, anti-inflammatory activity in the croton oil-induced ear edema test, and leukocyte migration into the intraperitoneal cavity. MF also presented anti-inflammatory activity in the croton oil-induced ear edema test. In conclusion, EES and MF have antinociceptive activity involving the opioid system and anti-inflammatory activity.
Highlights
Medicinal plants are o en used in order to replace or assist conventional therapies in the treatment of various diseases
Synadenium umbellatum Pax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of in ammation, pain, and several diseases. is study aimed to investigate the antinociceptive and anti-in ammatory activities of the ethanolic extract from Synadenium umbellatum Pax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail ick test, croton oil-induced ear edema test, and carrageenan-induced peritonitis test
EES reduced licking time in both phases of the formalin-induced paw licking test, but did not prolong the latency in the tail ick test. ese results show that EES presented antinociceptive activity, probably involving the opioid system, anti-in ammatory activity in the croton oil-induced ear edema test, and leukocyte migration into the intraperitoneal cavity
Summary
Medicinal plants are o en used in order to replace or assist conventional therapies in the treatment of various diseases. The preference for the use of medicinal plants may be related to their availability and low cost. Despite the preference of pharmaceutical companies for drug development using synthetic routes, in recent decades, a major concern of the market about the therapeutic potential of plants has been observed [3, 4]. Is fact has been proven by the evidence that nowadays about 25% of the prescribed drugs in the world are directly or indirectly obtained from plants. Brazil is privileged because it ranks rst among the richest countries in biodiversity in the world, accounting for 22% of the higher plant species on the planet [5]. E immense variety of plant, animal, and microorganism species in Evidence-Based Complementary and Alternative Medicine Brazil is privileged because it ranks rst among the richest countries in biodiversity in the world, accounting for 22% of the higher plant species on the planet [5]. e immense variety of plant, animal, and microorganism species in Evidence-Based Complementary and Alternative Medicine
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
