Abstract
Mikania scandens (L.) Willd. (Asteraceae), known as climbing hemp weed in English is a herbaceous climbing vine grown as a weed throughout the plains of the Indian subcontinent. The present study evaluated anti-nociceptive as well as central nervous system (CNS) activities of hydroalcoholic extract of flower from M. scandens (FMS) in Swiss albino mice. FMS (at 250 and 500 mg/kg body weight, i.p.) was evaluated for anti-nociceptive activity by acetic acid induced writhing and tail flick methods. Locomotor depressant activity was measured by means of an actophotometer. Skeletal muscle relaxant effect was evaluated by using rota-rod apparatus and sedative potentiating property by phenobarbitone-induced sleep potentiation study. The results of the present study revealed significant (p < 0.001) and dose dependent anti-nociceptive, locomotor depressant, muscle relaxant and sedative potentiating effects of FMS, demonstrating its depressant action on the murine CNS. From the present study, it can be concluded that the flower of M. scandens possessed prominent anti-nociceptive property along with marked depressant action on the CNS of mice.
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