Antinociceptive activity of Karpasa Beeja

Abstract

Background: Karpasa Beeja (cotton seeds) is a drug which is been used since Samhita period, it has Vatahara and Vedanasthapana properties. Acharya Charaka includes Karpasa in Brimhaniya Gana while Acharya Susruta includes it in Vatasamsamana Varga. Cotton seeds are a rich source of cattle feed. It is also widely used in preparation of Ayurvedic medicines. The present study is highly relevant in searching experimentally for its Anti-nociceptive activity in cotton seeds and its pharmacognostical, phytochemical, HPLC+TLC profile. Aim and objective: An experimental evaluation of Karpasa beeja for its Antinociception activity. Results: Acetic acid induced writhing test, mice was treated with paracetamol (72.5mg/Kg) and test Karpasa Beeja drug Kashaya (12.48ml/kg,) and distilled water as control group in a dose of 1ml. The efficacy of test substances for analgesic activity was evaluated in the swiss albino mice. The analgesic activity of Karpasa Beeja Kashaya was studied in swiss albino mice by administering the test substance orally. The writhing effect was induced by 1% V/V glacial acetic acid solution in mice pre-treated with test substance. The number of abdominal writhing were measure over 20 min after injection of acetic acid. Finally, percentage inhibition was calculated. Conclusion: In this test substance it is found that the percentage inhibition of pain is 38.89 % hence it can be concluded that the test substance is known to possess analgesic activity.