Abstract
Multi-component reactions (MCR) are effective methods for producing an enormous number of organic compounds in one step from simple and available starting materials [1]. Reactions using isocyanides, which lead to new types of heterocyclic systems, among which highly active compounds with various biological activity profiles are observed, are some of the leading MCRs [2]. The three-component synthesis based on isocyanides, carbonyl compounds, and acetylenedicarboxylate esters is an excellent example of an MCR on the basis of which a multitude of various heterocyclic compounds was recently produced [3]. Herein we present results from a study of the antinociceptive activity of dimethyl 7-aryl-2-(2-R-imino)-8[(3-aryl)quinoxalin-2-yl]-9-oxo-1,6-dioxaspiro[4.4]non-3,7-diene-3,4dicarboxylates (IIa-f), which were prepared by a three-component synthesis from 5-aryl-4-quinoxalin-2-ylfuran-2,3diones (Ia-c) [4], dimethyl acetylenedicarboxylate, and 1-adamantylisocyanide or o-methylphenylisocyanide according to the following reaction [5]:
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