Year-end Sale % OFF 
Abstract
Four dihydroxy flavone derivatives viz 5,3´-, 7,3´-, 2´,3´- and 2´,4´-dihydroxy flavones were evaluated for their antinociceptive response in doses ranging from 3 to 200 mg/kg (s.c). Antinociception in mice was studied employing acetic acid induced abdominal constrictions, formalin induced nociception and tail immersion assay procedures. Involvement of opioid mechanism in the antinociceptive action of dihydroxy flavones was investigated using naloxone in acetic acid assay. All the four tested dihydroxy flavones exhibited a significant, dose related antinociceptive response in these assay procedures. The inhibition of nociceptive response was more than 98% in acetic acid writhing assay and 100% in the chronic phase of formalin assay. Naloxone almost completely antagonized the antinociceptive response of the four-dihydroxy flavone compounds. In conclusion, all the four investigated dihydroxy flavones exhibited opioid mediated antinociceptive response in mice.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
