Abstract
Rhizomes of Alpinia calcarata Roscoe (Zingiberaceae) posses several bio-activities and are used in traditional medicine of Sri Lanka. However, their antinociceptive activity has not been investigated so far. The aim of this study therefore, was to examine the antinociceptive activity of hot water extract (HWE) and hot ethanol extract (HEE) of Alpinia calcarata rhizomes using rats and three models of nociception (tail flick, hot plate and formalin tests). Different concentrations of HWE (100, 250, 500, 750, 1000 mg/kg) and HEE (100, 250, 500, 750, 1000 mg/kg) were made and orally administrated to rats and the reaction times determined. The results showed that the extracts have marked dose-dependent antinociceptive activity, when evaluated in the hot plate and the formalin tests but not in the tail flick test. The antinociceptive effect was slightly higher in HEE than that of HWE. The antinociceptive effect was mediated via opioid mechanisms.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
