Abstract
A new compound containing a triene, a tetrahydropyran ring and glycine ester functionalities, restricticin B (1), together with four known compounds (2–5) were obtained from the EtOAc extract of the marine-derived fungus Penicillium janthinellum. The planar structure of 1 was determined by detailed analyses of MS, 1D and 2D NMR data. The relative and absolute configurations of 1 were established via the analyses of NOESY spectroscopy data, the comparison of optical rotation values with those of reported restricticin derivatives and electronic circular dichroism (ECD). All the compounds were screened for their anti-neuroinflammatory effects in lipopolysaccharide (LPS)-induced BV-2 microglia cells. Restricticin B (1) and N-acetyl restricticin (2) exhibited anti-neuroinflammatory effects by suppressing the production of pro-inflammatory mediators in activated microglial cells.
Highlights
The novel class of potent antifungal agents, restricticin and restricticinol, were first isolated from the fermentation broth of Penicillium restrictum [1,2]
Restricticin and lanomycin were first reported as natural antifungal agents to inhibit cytochrome P450
An extensive literature has indicated that 4-hydroxy-6-methyl-2-pyrone and glycine in 2-propanol in the presence of triethyl survey has indicated that 4-hydroxy-6-methyl-2-pyrone and glycine in 2-propanol in the presence of
Summary
The novel class of potent antifungal agents, restricticin and restricticinol, were first isolated from the fermentation broth of Penicillium restrictum [1,2]. These compounds contain a tetrahydropyran ring and triene side chains in common and restricticin possesses a glycine unit linked to the tetrahydropyran ring [3]. Activated microglia upregulate pro-inflammatory and neurotoxic infection or injury [11,12]. Activated microglia upregulate pro-inflammatory and neurotoxic mediators mediators including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6. Large numbers of activated microglia are microglia in theofCNS tissue of patients chronic neurodegenerative such as present inare thepresent.
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