Abstract
Abstract Sets of sera obtained from subjects vaccinated or infected with influenza A2 strains from 1957 to 1968 were examined by an improved hemagglutination inhibition procedure for measuring antineuraminidase antibodies with recombinant viruses, and by a neuraminidase inhibition test with human serum Cohn fraction IV-4 as substrate. Recombinants prepared with viruses containing 1957 and 1968 antigenic variants of neuraminidase were employed. The improved HI procedure was found to be as reliable as the NI test for detecting antineuraminidase antibody and antineuraminidase antibody increase. Antineuraminidase antibody was generally not found on first exposure to A2 strains but antibody increase occurred with increasing frequency during subsequent years. The antineuraminidase antibody response of man is broad, making recognition of antigenic enzymatic variants difficult by use of human serum.
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