Abstract
New complexes of dioxovanadium(V), zinc(II), ruthenium(II), palladium(II), and platinum(II) with 6-methylpyridine-2-carbaldehyde-N(4)-ethylthiosemicarbazone (HmpETSC) have been synthesized. The composition of these complexes is discussed on the basis of elemental analyses, IR, Raman, NMR (1H, 13C, and 31P), and electronic spectral data. The X-ray crystal structures of [VO2(mpETSC)] and [Pt(mpETSC)Cl] are also reported. The HmpETSC and its [Zn(HmpETSC)Cl2] and [Pd(mpETSC)Cl] complexes exhibit antineoplastic activity against colon cancer human cell lines (HCT 116).
Highlights
Interest in thiosemicarbazone chemistry has flourished for many years, largely as a result of its wide range of uses, for example, as antibacterial, antifungal, chemotherapeutic, and bioanalytical agents [1,2,3,4,5,6]
Zinc(II), palladium(II), and platinum(II) complexes of pyridine-2-carboxaldehyde thiosemicarbazone and substituted pyridine thiosemicarbazone were tested against human cancer breast and bladder cell lines and found to be selectively cytotoxic to these malignant cell carcinoma [7, 8]
We report the synthesis and spectroscopic characterizations of new complexes of 6-methylpyridine-2-carbaldehyde-N(4)ethylthiosemicarbazone (HmpETSC, Figure 1) with V(V), Zn(II), Ru(II), Pd(II), and Pt(II)
Summary
Interest in thiosemicarbazone chemistry has flourished for many years, largely as a result of its wide range of uses, for example, as antibacterial, antifungal, chemotherapeutic, and bioanalytical agents [1,2,3,4,5,6]. As the coordination of the metal ions to thiosemicarbazones improves their efficacy and improve their bioactivity [6] In this concept, zinc(II), palladium(II), and platinum(II) complexes of pyridine-2-carboxaldehyde thiosemicarbazone and substituted pyridine thiosemicarbazone were tested against human cancer breast and bladder cell lines and found to be selectively cytotoxic to these malignant cell carcinoma [7, 8]. We have previously studied the chemotherapeutic potential of a series of Mo(VI), Pd(II), Pt(II), and Ag(I) complexes with N,O; N,S and O,O-donors. These complexes were found to display significant anticancer activity against Ehrlich ascites tumor cell (EAC) in albino mice [9,10,11,12]. The anticancer activity of HmpETSC and its Zn(II) and Pd(II) complexes toward colon cancer human cell lines has been tested
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
