Abstract
Probiotic preparations were obtained on the basis of cryopreserved forms of pure cultures of L. plantarum and B. subtilis using freeze drying. The antimutagenic activity of the obtained probiotic preparations was investigated in relation to 1%, 0.1% and 0.01% concentrations of cobalt sulfate using the example of dominant lethal mutations of Drosophila. A positive antimutagenic effect of probiotic preparations was shown in relation to 0.1% and 0.01% concentrations of CoSO4 with an exposure duration of at least 3 days.
Highlights
Probiotic drugs are a promising alternative to chemotherapeutic drugs, agrochemicals, pesticides, and antibiotics, which are potentially hazardous to the health of people and farm animals.Chemicalization and intensification of industry and agriculture leads to an increase in the mutational load in populations of plants, animals, and humans, compensatory mechanisms in living beings that act against mutations are limited [1]
The obtained dry probiotic preparations were investigated for the presence of antimutagenic activity against cobalt sulfate at concentrations of 1%, 0.1% and 0.01% by taking into account the dominant lethal mutations (DLM) of Drosophila melanogaster wild type Canton-S from the laboratory collections of the Department of Biotechnology and Microbiology by the method of Belokon [3]
Analysis of the graphs showed that the greatest death of individuals in almost all samples is observed at the larval stage, with the exception of samples in which the offspring of males kept on probiotic preparations developed for 7 days
Summary
Probiotic drugs are a promising alternative to chemotherapeutic drugs, agrochemicals, pesticides, and antibiotics, which are potentially hazardous to the health of people and farm animals.Chemicalization and intensification of industry and agriculture leads to an increase in the mutational load in populations of plants, animals, and humans, compensatory mechanisms in living beings that act against mutations are limited [1]. The main goal was to identify the antimutagenic effect of dry probiotic preparations based on Lactobacillus plantarum and Bacillus subtilis cultures in relation to cobalt sulfate using the example of early and late embryonic lethal mutations in Drosophila.
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