Abstract
2-Deoxy-d-glucose (dGlc) is able to inhibit both N-acetyl-hexosamine-induced chlamydosporogenesis and N-acetyl-glucosamine- or proline-induced germ-tube formation in Candida albicans. This inhibition is exerted also at dGlc concentrations which do not affect growth in the yeast form and do not reduce either the uptake or the incorporation of N-acetyl-d-glucosamine (GlcNAc) into yeast or hyphal cell material. Inhibition of germtube formation by dGlc does not occur in serum and is fully reversed by glucose. It is suggested that dGlc acts as a potent antimorphogenic effector in C. albicans.
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