Antimony-Catalyzed Synthesis of Indanones in One Pot

Abstract

The authors report a highly stereoselective one-pot synthesis of trans-2,3-disubstituted indanone derivatives from phenylalkynes with aldehydes in one pot. Although one-pot approaches for the synthesis of indanones via Na­zarov cyclization of phenyl alkenyl ketone intermediates with stoichiometric amounts of promoters have been known as convenient methods, the authors develop the first catalytic one-pot approaches to the formation of indanones by a reaction of alkyne and aldehyde.