Abstract
Oxidative stress in the follicular fluid (FF) is thought to be responsible for the abnormal development of oocytes. In our study patients with polycystic ovarian syndrome (PCOS), endometriosis, and tubal infertility factor (TIF), and healthy women with a male factor of infertility, were prospectively enrolled. From each patient, a sample of individual FF was collected from a dominant follicle. Concentration levels of TAS, 8-IP, 8-OHdG, and AMH were determined. In women with PCOS, we found significantly lower values of oxidative stress markers in the FF. 8-IP and TAS levels were lower in the FF of women with endometriosis. In women with TIF, we also found significantly lower values of all tested markers in the FF, except for 8-OHdG and AMH. We wanted to see whether the biomarker measured in the FF in an individual diagnosis could predict a successfully obtained embryo from this particular follicle. The FF 8-OHdG result in PCOS patients stood out and proved to be a good predictive marker of matured and fertilized oocytes in these patients. Further research is needed to be able to apply the acquired knowledge in improving the outcome of IVF procedures.
Highlights
The overall prevalence of infertility is 12.5% among women and 10.1% among men, and this rate is rising
In women with polycystic ovarian syndrome (PCOS), we found significantly lower values of oxidative stress markers in the follicular fluid (FF). 8-IP and Total antioxidant status (TAS) levels were lower in the FF of women with endometriosis
We evaluate Oxidative stress (OS) in patients attended to In vitro fertilization (IVF) procedure according to different indicators and we have come up with some very interesting results
Summary
The overall prevalence of infertility is 12.5% among women and 10.1% among men, and this rate is rising. The causes vary; among female diagnoses the most common are ovulation disorders, including PCOS, as well as endometriosis and various fallopian tubes defects. The prevalence of those seeking help has been reported even above 50%.1. Oxidative stress (OS) has received extensive attention in the past two decades due to the discovery that abnormal oxidation status is related to patients with chronic diseases, such as diabetes, cardiovascular, polycystic ovary syndrome (PCOS), endometriosis, cancer, and neurological diseases.[3,4,5,6] Oxidative stress occurs when oxidants outnumber antioxidants, products of peroxidation develop, and pathological effects are caused by these phenomena. ROS are produced mainly within the mitochondrial electron transport chain and must be constantly deactivated to avoid excess formation to maintain normal cell function.[7]
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