Antimicrobials use and their indications in dairy farm and individual farmer production conditions in southern India.

Abstract

Antimicrobials use (AMU) is the key driver for development of antimicrobials resistant (AMR) pathogen in human and veterinary medicines. Therefore, understanding AMU pattern is prerequisite for focused intervention on AMR. The aim of this study was to understand the AMU pattern and their indications in dairy farm and individual farmer production conditions in southern India. Treatment registers of 6years (2012 to 2017) containing 3178 cases from dairy farm and 12,057 cases during 2017-2019 under individual farmer production conditions were collected and analyzed by log-linear model. Seasons were classified as rainy (Jul-Oct), winter (Nov-Feb), and summer (Mar-June) as per climatic conditions in the study area. It is observed that mastitis, lameness, and reproductive problems were major health disorders among treated animals in farm and individual farmer production conditions. Season had significant influence on proportional rates of various health disorders in crossbred cows under both the production conditions. AMU pattern was different between the breeds and production conditions. Antibiotics were the most commonly used group of drugs (23-28%) than non-steroidal anti-inflammatory drugs (20%), antihistamine (17%), and nutrient supplements (14-16%). Antibiotics were mostly used for mastitis (47-67%) than other conditions like fever (18%), reproductive problems (15%), and lameness (16%). For treating mastitis, cephalosporins and gentamicin were most commonly used under individual farmer production condition, while penicillin group was frequently used in farm. It is concluded that mastitis is the most common indication for AMU in dairy animals and thus developing appropriate guidelines for mastitis treatment and control is necessary to reduce overall AMU.