Antimicrobial to anti-herbivore: Sakuranetin in rice efficiently inhibits brown planthopper by targeting their beneficial endosymbionts.

Abstract

In rice, biosynthesis of specialized metabolites active against insect herbivores is elusive. The major known defense metabolites in rice against the destructive phloem-sucking herbivore brown planthoppers (BPH) (Nilaparvata lugens) are proteinase inhibitors, phenolamides and some terpenes (Xiao et al.,2012), which are induced during the invasion. Specifically, phenolamides were found to be induced upon herbivory with different feeding guild, including chewing and phloem-sucking, but could only provide defense against phloem-sucking BPH, though the clear mode of action of phenolamides has not been explored yet. Moreover, the jasmonic acid-mediated modulation of biosynthesis of these specialized metabolites in rice is not elucidated yet. However, a recent study by Liu et al.(2023) demonstrated that sakuranetin, a phytoalexin in rice, was induced upon BPH invasion and showed significant detrimental effect on herbivore's performance by targeting their beneficial endosymbionts. This is the first report on a strong bioactive anti-herbivore molecule observed in rice with an unusual mode of action. In this article, a view has been presented on this work, its impact and exceptionality.