ANTIMICROBIAL THERAPY OF PULMONARY TUBERCULOSIS: REVIEW OF SIX YEARS' EXPERIENCE AT FITZSIMONS ARMY HOSPITAL

Abstract

Article1 July 1953ANTIMICROBIAL THERAPY OF PULMONARY TUBERCULOSIS: REVIEW OF SIX YEARS' EXPERIENCE AT FITZSIMONS ARMY HOSPITALCARL W. TEMPEL, FORREST W. PITTS, WILLIAM E. DYECARL W. TEMPELSearch for more papers by this author, FORREST W. PITTSSearch for more papers by this author, WILLIAM E. DYESearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-39-1-61 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSix antimicrobial agents have been subjected to a methodical pattern of clinical investigation since 1946 at Fitzsimons Army Hospital. Approximately 1,300 patients have been evaluated under controlled conditions employing streptomycin, para-aminosalicylic acid, amithiozone, viomycin, terramycin and Isoniazid, either singly or in various combinations.1 Therapeutic efficacy, bacteriologic cultural and resistance studies, and toxicity formed the principal criteria for evaluating these drug regimens. Summary data on 875 patients observed on the research wards constitute the basis of this report.Studies were performed on a homogeneous group of patients relative to extent and clinical pathologic type of disease. Almost all were young adult...Bibliography1. Tempel CW: Present status of specific drug treatment of tuberculosis, J. A. M. A. 150: 1165-1170 (Nov. 22) 1952. CrossrefMedlineGoogle Scholar2. TempelHughesMardisTowbinDye CWFJREMNWE: Combined intermittent regimens employing streptomycin and para-aminosalicylic acid in the treatment of pulmonary tuberculosis, Transactions of the Ninth Streptomycin Conference (VA), 36-50 (Apr.) 1950. Google Scholar3. TempelHughesMardisTowbinDye CWFJREMNWE: Combined intermittent regimens employing streptomycin and para-aminosalicylic acid in the treatment of pulmonary tuberculosis; a comparison with daily and intermittent dosage schedules, Am. Rev. Tuberc. 63: 295-311 (Mar.) 1951. MedlineGoogle Scholar4. HughesMardisDyeTempel FJREWECW: Combined intermittent regimens in the treatment of pulmonary tuberculosis, Transactions of the 10th Conference on the Chemotherapy of Tuberculosis (VA), 67-76 (Jan.) 1951. Google Scholar5. HughesMardisDyeTempel FJREWECW: Combined intermittent regimens in the treatment of non-miliary pulmonary tuberculosis; a comparison of streptomycin every third day and para-aminosalicylic acid daily with streptomycin every third day and para-aminosalicylic acid every third day, Dis. Chest 21: 1-16 (Jan.) 1952. CrossrefMedlineGoogle Scholar6. D'EsopoRaleigh NDMD: Further experience with prolonged chemotherapy, Transactions of the Ninth Streptomycin Conference (VA), 56-66 (Apr.) 1950. Google Scholar7. O'DellPittsRowanDyeHughes ETFWAIWEFJ: The administration of amithiozone alone and in combination with intermittent streptomycin in non-miliary pulmonary tuberculosis, Transactions of the Eleventh Conference on Chemotherapy of Tuberculosis (VA), 332-337 (Jan.) 1952. Google Scholar8. PittsO'DellDyeHughesTempel FWETWEFJCW: Intermittent viomycin therapy in pulmonary tuberculosis; a preliminary report, Transactions of the Eleventh Conference on Chemotherapy of Tuberculosis (VA), 270-285 (Jan.) 1952. Google Scholar9. PittsO'DellDyeHughesTempel FWETWEFJCW: Intermittent viomycin therapy in pulmonary tuberculosis, Dis. Chest 23: 241-255 (March) 1953. CrossrefMedlineGoogle Scholar10. MillerSandsWalkerDyeTempel FLJHRWECW: Combined daily terramycin and intermittent streptomycin in the treatment of pulmonary tuberculosis; a preliminary report, Transactions of the Eleventh Conference on Chemotherapy of Tuberculosis (VA), 53-59 (Jan.) 1952. Google Scholar11. MillerSandsWalkerDyeTempel FLJHRWECW: Combined daily terramycin and intermittent streptomycin in the treatment of pulmonary tuberculosis, Am. Rev. Tuberc. 66: 534 (Nov.) 1952. MedlineGoogle Scholar12. PittsMillerDyeTempelFitzpatrick FWFLWECWMJ: Isoniazid therapy in pulmonary tuberculosis, U. S. Armed Forces M. J. 4: 1 (Jan.) 1953. MedlineGoogle Scholar13. PittsTempelMillerSandsFitzpatrickWeiser FWCWFLJHMJO: Isoniazid-streptomycin in the treatment of pulmonary tuberculosis: a preliminary report, J. A. M. A., in press. Google Scholar14. Pinner M: Pulmonary tuberculosis in the adult, 1945, Charles C. Thomas, Springfield, Illinois, p. 299. Google Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: *Read before the 119th Meeting of the American Association for the Advancement of Science, December 26, 1952, St. Louis, Missouri. Received for publication March 3, 1953.From the Medical Service and Research and Development Branch, Fitzsimons Army Hospital, Denver, Colorado. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byTrends in the Management of Pulmonary TuberculosisLONG-TERM OXYTETRACYCLINE (TERRAMYCIN) THERAPY IN ADVANCED CHRONIC RESPIRATORY INFECTIONSCurrent Concepts in the Treatment of Pulmonary TuberculosisATYPICAL TUBERCULOSIS OF THE LIVER WITH JAUNDICE*EDWARD A. CLEVE, JOHN R. GIBSON, WILLIAM M. WEBB 1 July 1953Volume 39, Issue 1Page: 61-73KeywordsAdverse reactionsAntimicrobialsHealth services researchIsoniazidMedical servicesStreptomycinToxicityYoung adults ePublished: 1 December 2008 Issue Published: 1 July 1953 PDF downloadLoading ...