Abstract
Various bacterial pathogens are responsible for nosocomial infections resulting in critical pathophysiological conditions, mortality, and morbidity. Most of the bacterial infections are associated with biofilm formation, which is resistant to the available antimicrobial drugs. As a result, novel bactericidal agents need to be fabricated, which can effectively combat the biofilm-associated bacterial infections. Herein, for the first time we report the antimicrobial and antibiofilm properties of silver-platinum nanohybrids (AgPtNHs), silver nanoparticles (AgNPs), and platinum nanoparticles (PtNPs) against Escherichia coli, Pseudomonas aeruginosa, and Staphylococcus aureus. The AgPtNHs were synthesized by a green route using Dioscorea bulbifera tuber extract at 100°C for 5 h. The AgPtNHs ranged in size from 20 to 80 nm, with an average of ∼59 nm. AgNPs, PtNPs, and AgPtNHs showed a zeta potential of −14.46, −1.09, and −11.39 mV, respectively. High antimicrobial activity was observed against P. aeruginosa and S. aureus and AgPtNHs exhibited potent antimicrobial synergy in combination with antibiotics such as streptomycin, rifampicin, chloramphenicol, novobiocin, and ampicillin up to variable degrees. Interestingly, AgPtNHs could inhibit bacterial biofilm formation significantly. Hence, co-administration of AgPtNHs and antibiotics may serve as a powerful strategy to treat bacterial infections.
Highlights
Nanobiotechnology has got wide attention due to multiple applications in electronics, catalysis, textiles, food industries, and therapeutics
In this work the result showed that the activity of the biogenic silver-platinum bimetallic nanohybrids (AgPtNHs) were synthesized by using aqueous extract of D. bulbifera tuber to evaluate their antimicrobial synergy in combination with the antibiotics against both Gram-positive and Gramnegative bacterial pathogens
The nanocluster shaped AgPtNHs were monodispersed with an average diameter of ∼59 nm
Summary
Nanobiotechnology has got wide attention due to multiple applications in electronics, catalysis, textiles, food industries, and therapeutics. Silver nanoparticles (AgNPs) are used in biosensing, biomedical imaging, and drug delivery (Tarannum et al, 2019). AgNPs are used for designing antimicrobial surfaces, cosmetics, paints, and plastics. Because of their bactericidal and fungicidal properties, AgNPs are used for the fabrication of wound dressings (Wilkinson et al, 2011; Robkhob et al, 2020). Platinum nanoparticles (PtNPs) are known for their excellent antimicrobial activity and ability to inhibit the growth of unwanted and harmful bacteria (Tahir et al, 2017)
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