Antimicrobial susceptibility testing in clinical Mycobacterium tuberculosis isolates

Abstract

Whole-genome sequencing (WGS) for prediction of drug resistance in Mycobacterium tuberculosis clinical isolates might contribute to the timely diagnosis and correct treatment of all tuberculosis cases. In 2021, the first catalogue of resistance-associated mutations in clinical M tuberculosis complex isolates was published by WHO,1 which provided a global standard for resistance interpretation. We read with interest the Article by Finci and colleagues2 reporting a good correlation between resistance genotype with phenotypic antimicrobial susceptibility testing (AST) using a large, longitudinal survey of M tuberculosis isolates from five countries.