Abstract
BackgroundMycoplasma (M.) hyopneumoniae, M. hyorhinis and M. hyosynoviae are significant pathogens for the porcine industry worldwide. The aim of the present study was to determine the antimicrobial susceptibility of six key antimicrobials (tylosin, tilmicosin, tylvalosin, lincomycin, tiamulin and valnemulin) routinely used for treating infections caused by these pathogens. Twenty-seven M. hyopneumoniae, 48 M. hyorhinis and 40 M. hyosynoviae field strains isolated from clinical samples from different Southern European countries between 2013 and 2018 using broth microdilution method were evaluated.ResultsTylvalosin exhibited the highest in vitro activity among the macrolides assayed, with MIC90 values 4 to 5 two-fold dilutions lower than those of tylosin and tilmicosin. The pleuromutilin valnemulin showed one of the highest in vitro activities against the three mycoplasma species. On the contrary, lincomycin exhibited the highest MIC values of the antimicrobials tested.ConclusionsThe data obtained in the present study supports the use of pleuromutilins and macrolides for the control of infections caused by porcine mycoplasmas. The use of lincomycin for the treatment of porcine mycoplasma infections should be carefully evaluated due to the presence of circulating field isolates with decreased susceptibility to this antimicrobial.
Highlights
Mycoplasma (M.) hyopneumoniae, M. hyorhinis and M. hyosynoviae are significant pathogens for the porcine industry worldwide
Mycoplasma strains A total of 27 M. hyopneumoniae isolates were obtained from cases of porcine respiratory disease
Lincomycin Minimum inhibitory concentration (MIC) showed a wide range of dilutions, ranging from 0.06 to 16 μg/ml, including the highest MIC value of all M. hyopneumoniae strains tested
Summary
Mycoplasma (M.) hyopneumoniae, M. hyorhinis and M. hyosynoviae are significant pathogens for the porcine industry worldwide. Mycoplasma (M.) hyopneumoniae, M. hyorhinis and M. hyosynoviae are considered the most relevant Mollicutes to porcine health worldwide, and together with M. suis, a non-culturable haemotropic mycoplasma, represent the main pathogenic mycoplasmas of pigs [1, 2]. The historical overuse of antibiotics in human and animal medicine has led to a current situation of alert, due to the development of resistance that reduces the therapeutic options In this scenario, the analysis and monitoring of antimicrobial susceptibility has become pivotal in animal health management [13]. The aim of this study was to evaluate the in vitro activity of some of the most relevant antimicrobials used in cases of porcine mycoplasmosis against mycoplasma field strains isolated from Italian, Portuguese and Spanish clinical samples collected between 2013 and 2018
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