Abstract
The susceptibility profile of 763 Stenotrophomonas maltophilia isolates was evaluated against 16 antimicrobials by the CLSI reference broth microdilution method. Minocycline (MIC90, 1 μg/ml; 100.0% susceptible) was the most active compound, followed by doxycycline (MIC90, 4 μg/ml; 99.6% susceptible), trimethoprim/sulfamethoxazole (MIC90, 1 μg/ml; 97.8% susceptible), and tigecycline (MIC90, 2 μg/ml). An excellent correlation between levofloxacin (MIC90, 4 μg/ml; 86.5% susceptible by published breakpoint criteria) and moxifloxacin (MIC90, 2 μg/ml) MIC results was observed indicating that moxifloxacin could be further evaluated as a therapeutic option for S. maltophilia infections.
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