Abstract
Background We studied the susceptibility profile of Aerococcus urinae recovered from urinary clinical samples with the aim of providing guidance in the choice of empiric antimicrobial treatment for urinary tract infection (UTI). Methods We studied stored isolates collected from UTIs of adult male and female VA patients of varying race/ethnicities from January 2019 to January 2021. Susceptibility of antimicrobials in the GPALLF3 Sensititre tray was determined. Minimum Inhibitory Concentration were interpreted based on breakpoints for Aerococcus species as outlined in the CLSI M45 standard and Streptococcus species viridans group or Enterococcus species, as outlined in the CLSI M100 standard. Results A total of 64 unique A. urinae isolates were recovered from the stored isolates. All isolates were susceptible to ampicillin, penicillin, linezolid, nitrofurantoin, and vancomycin, while 92.1% were susceptible to tetracycline, 63.6% to levofloxacin, and 44.5% to ciprofloxacin. Conclusions Our findings lead us to suggest the use of ampicillin, tetracycline, and nitrofurantoin for the empirical treatment of lower UTI caused by A. urinae.
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