Antimicrobial susceptibility of P. aeruginosa isolated from patients with respiratory tract infections

Abstract

P. aeruginosa is a gram negative rod non-fermenter bacterium that commonly cause opportunistic hospital acquired infection. The antibiotic susceptibility of bacteria frequently changes over time and differs from place to place so regular surveillance of antibiotic susceptibility in institute is needed to treat the infection empirically and efficiently. Objectives: 1) To determine frequency of respiratory tract infections by P.aeruginosa 2) To determine antimicrobial susceptibility of P. aeruginosa isolated from patients with respiratory tract infections 3) To determine antimicrobial susceptibility of P. aeruginosa isolates of respiratory tract infections in indoor versus outdoor patients 4) To determine antimicrobial susceptibility of P. aeruginosa isolates from patients with respiratory tract infections from various clinical departments. 5) To determine frequency of respiratory tract infections by multi drug resistant (MDR) P. aeruginosa Material and Methods: A total of 66 P. aeruginosa isolated from clinical specimens from patients of respiratory tract infections were included in the presents study and antibiotic susceptibility of the isolates was determined by Clinical Laboratory and Standard Institute [CLSI] guidelines. Data including patient’s age, gender, organism and antibiotic susceptibility results were collected, and analyzed using Microsoft Excel 2007, and Whonet 5.6. Results: Prevalence of P. aeruginosa in respiratory tract infections is 26%. In present study, P. aeruginosa isolates showed highest sensitivity towards Colistin (100%), followed by Meropenem (98.4%), Piperacillin/Tazobactam (98.4%), Ciprofloxacin (98.4%), Ceftazidime (93.8%), Cefoperazone (94.8%), and Amikacin (92.2%), and lowest sensitivity towards to Piperacillin (90.6%) and Ticarcillin (87.5%) observed. P. aeruginosa from indoor patients showed higher resistance towards antipseudomonal drugs than isolated from outdoor patients. There is difference in antibiotic sensitivity of P. aerugi