Abstract
Multidrug-resistant (MDR) Acinetobacter baumanii (A. baumanii) caused hospital acquired infection, typically in critical-ill patients with medical devices. This is a retrospective descriptive study on epidemiology and microbiology data to determine the antimicrobial susceptibility pattern of MDR-Acinetobacter baumanii isolates from a teaching hospital in Tangerang, Indonesia from Januari 2013 to December 2014. A total of 84 A. baumanii were collected. Patients suffering from respiratory tract infection had the highest number (41.7%) of A. baumanii isolate. There were 39 (46.6%) patients admitted in critical care. A. baumanii isolates in this study mostly were multidrug-resistant organisms with low susceptibility level to 11 antibiotic tested, 44% - 69% in 2013 and 26% - 67% in 2014. A high susceptibility level was observed to amikacin (80% and 79% in 2013, 2014 consecutively) and trimethoprim-sulfamethoxazole (73% and 72% in 2013, 2014 consecutively). A. baumanii is a hospital acquired pathogen in critically-ill patients. The susceptibility pattern of this study result showed MDR organism. There was a sharp decrease of susceptibility in all antibiotics studied from 2013 to 2014 except amikacin and trimethoprim-sulfamethoxazole.
Highlights
Acinetobacter baumnaii (A. baumanii) is an opportunistic Gram-negative pathogen which has implicated in aHow to cite this paper: Cucunawangsih, Wiwing, V. and Lugito, N.P.H. (2015) Antimicrobial Susceptibility of Multidrug-Resistant Acinetobacter baumanii in a Teaching Hospital: A Two-Year Observation
The highest number isolate of MDR-A. baumanii infection was observed in patients suffering from respiratory tract infection who were using endotracheal tube and admitted in critical care (41.7%)
Urinary tract infection caused by MDR-A.baumnaii (1.2%) while blood stream infection (8.3%)
Summary
Acinetobacter baumnaii (A. baumanii) is an opportunistic Gram-negative pathogen which has implicated in aHow to cite this paper: Cucunawangsih, Wiwing, V. and Lugito, N.P.H. (2015) Antimicrobial Susceptibility of Multidrug-Resistant Acinetobacter baumanii in a Teaching Hospital: A Two-Year Observation. (2015) Antimicrobial Susceptibility of Multidrug-Resistant Acinetobacter baumanii in a Teaching Hospital: A Two-Year Observation. The emergence and rapid spread of Multidrug-resistant (MDR) A. baumanii causing a serious clinical problem in hospital acquired infection which is leading to an increased mortality with crude mortality rates parallel those attributed to other gram-negative bacilli (28% - 32%) [6] [7]. The susceptibility level of major group antibiotics used for treatment decreased rapidly and implicated in limited selection of empirical antibiotic therapy [8]. The information of these organisms and antibiotic susceptibility pattern among hospitalized patients in Indonesia is hard to find. This study was designed to determine the prevalence of MDR-A. baumanii and its antibiotic susceptibility pattern from a teaching hospital in Tangerang, Indonesia from January 2013 to December 2014
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