Abstract
BackgroundKazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Although antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information on a circulation of the antibiotic-resistant Brucella strains in the Central Eurasia. In this article we describe an occurrence of the drug resistance of Brucella melitensis isolates in Kazakhstan which is among the largest countries of the region.MethodsSusceptibilities to tetracyclin, gentamycin, doxycyclin, streptomycin and rifampicin were investigated in 329 clinical isolates of Brucella melitensis using E-test method.ResultsAll isolates were susceptible to streptomycin, tetracycline and doxycycline. 97.3% of the Brucella isolates were susceptible to gentamycin, although only 37.4% of isolates were susceptible to rifampicin. 21.9% of isolates had intermediate resistance, and 26.4% of isolates were resistant to this antibacterial drug.ConclusionIsolates of Brucella melitensis circulating in Kazakhstan are susceptible to streptomycin, doxicyclin, tetracyclin and gentamycin. At the same time the resistance to rifampicin is widespread, almost half of the isolates were rifampicin-resistant (including the intermediate resistance).
Highlights
Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals
All 329 strains were susceptible to streptomycin, tetracycline and doxycycline and the mentioned antibiotics exhibited high antimicrobial activity
97.3% of the isolates were susceptible to gentamicin, only 2.7% were resistant to gentamicin
Summary
Kazakhstan belongs to countries with a high level of brucellosis among humans and farm animals. Antibiotic therapy is the main way to treat acute brucellosis in humans there is still little information on a circulation of the antibiotic-resistant Brucella strains in the Central Eurasia. In this article we describe an occurrence of the drug resistance of Brucella melitensis isolates in Kazakhstan which is among the largest countries of the region. One obstacle to the antibiotic therapy is that Brucella can survive in intracellular environments and replicate in macrophages and dendritic cells. For this reason the antibiotics must have intracellular activity. The treatment regiments currently recommended by the WHO use a combination of doxycycline and rifampicin for 6 weeks, or doxycycline for 45 days and streptomycin for 21 days
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