Abstract

In NICUs, antibiotics are the most frequently prescribed medications. Misuse or overuse of antibiotics may lead to resistant species and other life-threatening complications and untoward effects. Antimicrobial stewardship programs-coordinated programs that promote the appropriate use of antimicrobials (including antibiotics)-have reduced unnecessary medication administration, costs, readmissions, complications, and mortality rates related to antimicrobial agents, predominantly among adult patients in many hospitals. At the same time, however, implementation of antimicrobial stewardship programs among preterm infants has been challenging, especially for staff nurses in NICUs. This article provides an overview of the literature addressing the concept of stewardship, outlines core elements of antibiotic stewardship programs from the Centers for Disease Control and Prevention, and examines strategies for nursing implementation in NICUs focusing on preterm infants.

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