Abstract

Antimicrobial resistance is a serious threatening problem associated with high morbidity and mortality. The majority of pathogenic bacteria show multiple drug resistance patterns. Thus, treatment of infections caused by those bacteria become ineffective. This paper evaluates, investigates, and discusses the existing situation of antimicrobial resistance in Gaza Strip, Palestine. The data of this review considered the published articles over the period 2002-2021. Search was conducted using Google scholar, Researchgate, and PubMed search engines. Thirty five articles were included. This review discussed studies done on antibiotic resistant bacteria found in a wide range of environments including clinical samples, foods, poultry, costal water, hospital wastewater, and hospital environments. The reported dissemination and spread of antibiotic resistant bacteria is influenced by several factors like inappropriate and unwise use of antibiotics as well as the un-regulated access of these antibiotics to the environment. Palestine is in urgent need to develop, strengthen, and implement antimicrobial stewardship policy, standard treatment guidelines, a local plan for containment and reduction of antimicrobial resistance, and research related to public health aspects of antimicrobial resistance at the community and hospital level. Keywords; Antimicrobial resistance, Gaza strip, Palestine

Highlights

  • Bacterial ability to resist and overcome antimicrobial agents has been noticed since the development of these agents and their approval for use in the clinical field [1]

  • The overall results of these studies have shown a high rates of multidrug-resistant gramnegative bacteria especially E. coli, Enterobacter spp., Kebsiella spp., Acinetobacter spp. and Pseudomonas aerugineosa over the study period

  • There is an urgent need to develop a local plan for containment of antimicrobial resistance by implement antimicrobial stewardship

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Summary

Introduction

Bacterial ability to resist and overcome antimicrobial agents has been noticed since the development of these agents and their approval for use in the clinical field [1]. Additional factors contributing to the increased burden of bacterial resistance in developing countries are the weakened health infrastructure, behind scheduled presentations, the limited access to diagnostics (especially microbiology), and the reduced availability of second-line antibiotics [5]. This alarming phenomenon may be caused by antibiotics use in animal feed, inappropriate prescribing of antibiotics, and poor infection control strategies [6]. A critical high rates of pathogenic bacteria isolates in Palestine are showing multiple drug resistance patterns This fact will complicate treatment of patients suffering from bacterial infections

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