ANTIMICROBIAL RESISTANCE OF ANAEROBIC BACTERIA ISOLATED AT VIET DUC UNIVERSITY HOSPITAL

Abstract

Objectives: To evaluate the antibiotic susceptibility of anaerobic bacteria strains isolated from clinical specimens at Viet Duc University Hospital. Subjects and methods: A descriptive study and lab analysis on 167 anaerobic isolates isolated from clinical specimens. Results: The highest rate of resistance to the isolates was observed for metronidazole (84.43%), followed by clindamycin (49.7%) and antibiotics in the carbapenem group (2.99% - 8.98%), respectively. The lowest rate of resistance was shown for piperacillin/tazobactam (1.2%). However, the rate of resistance to antibiotics was variable in isolated strains. In more detail, amoxicillin/clavulanate varied from 0.00% - 10.53%, piperacillin/tazobactam (0.00% - 2.17%), metronidazole (78.95 % - 93.75%), carbapenems (0.00% - 12.50%), moxifloxacin (0.00% - 10.53%), and clindamycin (40.00% - 85.42%). The susceptibility to metronidazole was 80.43% in 46 Bacteroides isolates and 4.17% in 48 Prevotella isolates. Compared to other antibiotics, the resistance to metronidazole is significantly high, specifically for Prevotella, with the highest rate of 93.75%. Conclusion: The rate of resistance to antibiotics in pathogenic anaerobic bacterial isolates fluctuated with amoxicillin/clavulanate (0.00% - 10.53%), piperacillin/tazobactam (0.00% - 2.17%), carbapenems (0.00% - 12.50%), moxifloxacin (0.00% - 10.53%), and clindamycin (40.00% - 85.42%). The resistance varied in different strains. Prevotella and Micromonas were shown to be less resistant to antibiotics than Bacteroides and Clostridium.