Abstract
BackgroundThe rate of antimicrobial resistant isolates among pathogens causing urinary tract infections (UTIs) in Democratic Republic of Congo (DRC) is not known. The aim of the current study was to determine this rate at the Bukavu Provincial General Hospital (province of South-Kivu, DRC).FindingsA total of 643 isolates (both from inpatients and outpatients) collected from September 2012 to August 2013 were identified using biochemical methods, and tested for antimicrobial susceptibility. The isolates were further screened for Extended-Spectrum Beta-Lactamases (ESBL) production. Beta-lactamase AmpC phenotype was investigated in 20 antibiotic-resistant isolates.Escherichia coli (58.5%), Klebsiella spp. (21.9%) and Enterobacter spp. (16.2%) were the most frequent uropathogens encountered. Rare uropathogens included Citrobacter spp., Proteus spp., and Acinetobacter spp. Resistance was significantly more present in inpatients isolates (22.1% of isolates) when compared to outpatients isolates (8.4% of isolates), (p-value <0.001). Antibiotic-resistant isolates displayed resistance to common antimicrobial drugs used for UTIs treatment in South Kivu province, namely: ciprofloxacin, ampicillin and third generation cephalosporins. ESBL-phenotype was present in 92.9% of antibiotic-resistant isolates. Only amikacin, nitrofurantoin and imipenem displayed satisfactory activity against antibiotic resistant isolates.ConclusionsThis study confirms the presence of antibiotic-resistant uropathogens (mainly ESBL-producers isolates) at the Bukavu General Hospital. This study should serve as a wake-up call and help to raise awareness about the threat to public health of antibiotic resistance in this DRC province.
Highlights
Urinary tract infections (UTIs) refer to any type of urothelial inflammatory response resulting from the invasion of the urinary tract by microbial pathogens [1,2]
This study confirms the presence of antibiotic-resistant uropathogens at the Bukavu General Hospital
This study should serve as a wake-up call and help to raise awareness about the threat to public health of antibiotic resistance in this Democratic Republic of Congo (DRC) province
Summary
Urinary tract infections (UTIs) refer to any type of urothelial inflammatory response resulting from the invasion of the urinary tract by microbial pathogens [1,2]. They are considered to be the most common bacterial infections worldwide, whether in the community or hospital setting [3,4,5]. The aim of this study was to monitor the rate of resistant urinary pathogens isolated from patients with UTIs (both from community and hospital settings) attending Bukavu Provincial Hospital (South Kivu, DRC) from September 2012 to August 2013, as well as to determine the pattern of antibiotic resistance to commonly used antimicrobial agents in the province. The aim of the current study was to determine this rate at the Bukavu Provincial General Hospital (province of South-Kivu, DRC)
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