Abstract
Patterns of antimicrobial resistance (AMR) regarding Pasteurella multocida (n = 345), Mannheimia haemolytica (n = 273), Truperella pyogenes (n = 119), and Bibersteinia trehalosi (n = 17) isolated from calves, cattle and dairy cows with putative bovine respiratory disease syndrome were determined. The aim of this study was to investigate temporal trends in AMR and the influence of epidemiological parameters for the geographic origin in Bavaria, Germany, between July 2015 and June 2020. Spectinomycin was the only antimicrobial agent with a significant decrease regarding not susceptible isolates within the study period (P. multocida 88.89% to 67.82%, M. haemolytica 90.24% to 68.00%). Regarding P. multocida, significant increasing rates of not susceptible isolates were found for the antimicrobials tulathromycin (5.56% to 26.44%) and tetracycline (18.52% to 57.47%). The proportions of multidrug-resistant (MDR) P. multocida isolates (n = 48) increased significantly from 3.70% to 22.90%. The proportions of MDR M. haemolytica and P. multocida isolates (n = 62) were significantly higher in fattening farms (14.92%) compared to dairy farms (3.29%) and also significantly higher on farms with more than 300 animals (19.49%) compared to farms with 100 animals or less (6.92%). The data underline the importance of the epidemiological farm characteristics, here farm type and herd size regarding the investigation of AMR.
Highlights
Bovine respiratory disease (BRD) is one of the most significant health problems in bovine medicine worldwide [1]
Between July 2015 and June 2020, a total of 754 isolates were collected from 662 animals with suspected BRD syndrome, origination from 519 farms were included in the present
The amendment to the 2018 “Tierärztliche Hausapothekenverordnung”, a national German law, obliges veterinarians to ensure the efficacy regarding antimicrobial therapy applying prior resistance testing under certain conditions [49]. This legal change is visible, in our study, as the number of all tested bacterial isolates sent to our laboratory has increased since the third investigation year with 151 isolates compared to 197 isolates in the following observation period (Table 1)
Summary
Bovine respiratory disease (BRD) is one of the most significant health problems in bovine medicine worldwide [1]. The syndrome causes significant economic losses in both beef and dairy production farms [2,3]. Stressful conditions are involved in the development of BRD, such as commingling of calves from different sources or transports over long distances [7,9]. Viral agents, such as bovine parainfluenza virus type 3 (PI-3), bovine respiratory syncytial virus (BRSV), bovine herpes virus type 1 (BHV-1), bovine viral diarrhea virus (BVDV) and bovine coronavirus (BCoV) are associated with BRD and may promote secondary bacterial infections by impairing the animals’ immune system [8,10,11,12]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
