Abstract

The effectiveness of antibiotic therapy is constantly decreasing due to the increasing spread of resistant pathogens. One alternative treatment for infections is the use of probiotics - living microorganisms that contribute to the normalization of the human microbiota. The aim of this study is to determine the antibiotic properties of the strain 534 as the intended basis of its probiotic activity.

Highlights

  • The use of antibiotics in medicine began during the Second World War, but over the past decades, the effectiveness of antibiotic therapy is constantly decreasing due resistance development of pathogenic microorganisms [1,2,3]

  • No activity against Gram-negative bacteria was detected in the culture liquid (CL), such activity was detected after CL concentration of approximately 800 times including activity against some clinical isolates of multidrug-resistant bacteria of the Klebsiella pneumonia and Acinetobacter baumannii species

  • Velopment and introduction of new antibiotics into the medical practice, as well as other antimicrobial drugs. The latter include probiotics - drugs, which are based on living microorganisms that contribute to the normalization of the human microbiota

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Summary

Introduction

The use of antibiotics in medicine began during the Second World War, but over the past decades, the effectiveness of antibiotic therapy is constantly decreasing due resistance development of pathogenic microorganisms [1,2,3]. Antimicrobial Properties of the Probiotic Strain Bacillus Subtilis 534. Velopment and introduction of new antibiotics into the medical practice, as well as other antimicrobial drugs. The latter include probiotics - drugs, which are based on living microorganisms that contribute to the normalization of the human microbiota. One alternative treatment for infections is the use of probiotics - living microorganisms that contribute to the normalization of the human microbiota. The aim of this study is to determine the antibiotic properties of the strain 534 as the intended basis of its probiotic activity

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