Abstract
Objective: This work aims at the screening of the antimicrobial activity of the seven brown marine algae of theCoast of Sidi Bouzid (El Jadida-Morocco).
 Methods: The aim of this study was to evaluate the antimicrobial activity of seven brown marine algae against three Gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus and Streptococcus pyogenes). Three Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumonia) and two fungi (Aspergillus Niger and Candida tropicalis). Thus, 35 algal extracts were prepared with five organic solvents methanol/water, methanol, dichloromethane/methanol, dichloromethane and ethyl acetate. The antibacterial activity was evaluated through the disk diffusion method.
 Results: Data revealed that the Staphylococcus aureus bacteria was the most sensitive pathogen by showing the highest zone of inhibitions of 20 mm with the lowest Minimum Inhibitory Concentration (MIC) of 2 μgmL⁻¹ methanol/water extract of Cystoseira tamariscifolia. Whereas, antifungal activity, the highest zone of inhibitions of 21 mm and 22 mm with the lowest Minimum Inhibitory Concentration (MIC) of 5 μgmL-¹ was respectively shown in the methanol/water extract of Laminaria ochroleuca against Candida tropicalis and in the dichloromethanolic extract of Sargassum vulgare against Aspergillus niger.
 Conclusion: The results indicate that these algal extracts can further be analyzed and purified for relevant antibacterial and antifungal compounds which can be used in therapeutics and other applications.
Highlights
Marine species, comprising approximately a half of the total global biodiversity, are a rich source of structurally diverse bioactive compounds with various biological activities
The paper described the antimicrobial activity of seven brown algae collected from the coast of Sidi Bouzid El Jadida against clinical multidrug resistant bacteria and fungi
The antibacterial activity of thirty five organic extracts (methanol/water (40/60), methanol, dichloromethane/methanol (50/50), dichloromethane and ethyl acetate), obtained from seven seaweeds species against six pathogenic bacteria was studied in comparison to the reference drugs Streptomycin (100μg) and Ofloxacine (50μg)
Summary
Marine species, comprising approximately a half of the total global biodiversity, are a rich source of structurally diverse bioactive compounds with various biological activities. Their importance as a source of novel bioactive substances is growing rapidly. Algae are rich sources of bioactive compounds with various biological activities. Their value as a source of novel bioactive substances has become important. Researchers have revealed that marine algal originated compounds exhibit various biological activitie [1,2,3]. Most of the secondary metabolites biosynthesized by the marine algae are well-known for their cytotoxic [4], anti-inflammatory [5,6,7,8] property, their numerous studies have revealed the anti-bacterial [913], antifungal activity [14, 2, 3] and antioxidant [15, 16] properties in different macro-algae
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