Abstract
In this article, there are two new levofloxacin (HLevo) complexes were synthesized and spectroscopically discussed. These complexes were prepared in alkaline state (pH = 8) with the 1:1 stoichiometry between zirconyl(II) or indium(III) chloride and pure HLevo antibiotic drug ligand in mixed solvent equal volumes from methanol and bi-distilled water. The structures interpretation were performed based on the micro analytical (elemental analyses), molar conductance and spectroscopic measurements. It is shown that the deprotonated HLevochelate was coordinated towards ZrIV and InIII metal ions, this occurs as a bidentate ligand through the oxygen atoms of carboxylate and carbonyl group, respectively. Accordingly, these complexes can be speculated as [ZrO(Lev)(Cl)(H2O)] · H2O (1) and [In(Lev)(Cl)2(H2O)2] (2). Through Tranmission Electron Microscopy (TEM) imaging it is demonstrated that the nanoscale particles have a homogeneous distribution across the complex surface. Furthermore, by assessing in vitro antimicrobial activities, the inhibition activity of HLevo drug ligand as well as the associated metal ion complexes were evaluated towards specific types of bacteria and fungi.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.