Abstract
The necessity to manufacture graft materials with superior biocompatibility capabilities and biodegradability characteristics for tissue regeneration has led to the production of extracellular matrix- (ECM-) based scaffolds. Among their advantages are better capacity to allow cell colonization, which enables its successful integration into the tissue surrounding the area to be repaired. In addition, it has been shown that some of these scaffolds have antimicrobial activity, preventing possible infections; therefore, it could be used as an alternative to control surgical infection and decrease the use of antimicrobial agents. The purpose of this review is to collect the existing information about antimicrobial activity of the ECM and their components.
Highlights
Every year, millions of patients suffer traumatisms, diseases, or infections that lead to the loss of tissues such as skin [1], bone [2], nerves [3], cartilage [4], liver [5], and blood vessels, among others [6]
These scaffolds are produced from extracellular matrix (ECM) of a wide variety of tissues, including the small intestine submucosa (SIS) [17], urinary bladder matrix (UBM) [18], central nervous system [19], esophagus [20], liver [21], skeletal muscle [22], lung [23], umbilical cord [24], adipose tissue [25], dermis [26], colon [27], cartilage [28], and bone [29], among others
extracellular matrix- (ECM-)based scaffolds from different sources have been tested for their capacity to control surgical infection, since it has been observed that this kind of graft has the capacity to generate antimicrobial peptides that protect the remodeling site [41, 45, 52], through a controlled release mechanism of enzymatic digestion [46, 53, 54]. is could lead to a new alternative to decrease the treatment with antimicrobials and improve the clinical prognosis
Summary
Millions of patients suffer traumatisms, diseases, or infections that lead to the loss of tissues such as skin [1], bone [2], nerves [3], cartilage [4], liver [5], and blood vessels, among others [6]. A therapeutic strategy could be the use of decellularized tissue scaffolds; these have demonstrated to provide macroand microenvironmental signals at compositional and structural level [16] These scaffolds are produced from extracellular matrix (ECM) of a wide variety of tissues, including the small intestine submucosa (SIS) [17], urinary bladder matrix (UBM) [18], central nervous system [19], esophagus [20], liver [21], skeletal muscle [22], lung [23], umbilical cord [24], adipose tissue [25], dermis [26], colon [27], cartilage [28], and bone [29], among others. Due to its great properties to repair and exert antimicrobial activity, ECM can be considered an ideal material for tissue regeneration to prevent infections. is review will be focused on describing those ECM-based scaffolds, components, and bioactive peptides with antimicrobial activity (Table 1)
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
