Abstract
Search for developing new antimicrobial polymers and designing new antimicrobial materials is an important research area to overcome bacterial resistance. In the present study a new polymer, poly(4–Vinyl–2–pyridone), having bioactive structure analogous to the naturally occurring heterocyclic compounds, was synthesized from 4–Vinylpyridine following a simple protocol. To augment the antibacterial properties of the synthesized polymer, N–alkylation of the heterocyclic pyridone moieties was achieved with ethylene chlorohydrin (2–Chloroethanol) to generate choline analogous structure. Also, its N–Butylated analogue was synthesized as a reference compound to study structure–activity relationship. Structure of the polymers was confirmed by different characterization techniques. Antimicrobial efficacy of the polymers was determined by minimum inhibitory concentration method in parallel experiments. The test microorganisms used were Gram (+) bacterium (Staphylococcus epidermidis), Gram (−) bacteria (Salmonella typhi, Pseudomonas aeruginosa and Escherichia coli) and fungus (Candida albicans). Both the polymer derivatives are far more effective antimicrobial agents than the pristine polymer. Trends in the antimicrobial efficacy of these polymers correlate with their zeta potential values.
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