Antimicrobial Profile of Clostridium perfringens Isolates from Milk and Milk Products

Abstract

The aim of the present study was to observe the antimicrobial profile of 21 isolates of C. perfringens from 250 samples of milk and milk products from Jabalpur city. Isolates were subjected to antimicrobial susceptibility test using disc diffusion technique. In vitro antimicrobial assay against 16 antibiotics revealed that isolates were sensitive to ciprofloxacin (95.23%), ofloxacin (76.19%) and vancomycin (61.90%) and isolates were resistant to amoxicillin (76.19%), ceftazidime (71.42%) and co-trimoxazole (47.61%). The isolates displayed multidrug and Multiple antibiotic resistance (MAR). The MAR index for different isolates revealed that 15 (71.42%) isolates have MAR index greater than 0.2 and 6 (28.57%) isolates have less than 0.2. The higher resistance of C. perfringens isolates towards amoxicillin, ceftazidime and co-trimoxazole is of great concern as these antimicrobials are commonly used in therapeutic management.